Researcher Develops Mathematical Model to Combat Keloid Scar Growth

Keloid scars, a persistent problem in biology and healthcare, took center stage during a recent University of California meeting. These scars, which can develop from even minor injuries like ear piercings, are not only uncomfortable and itchy but can also severely impact self-esteem. Unfortunately, surgical removal often exacerbates the issue, leading to even larger scars.

In a groundbreaking approach, a researcher presented a computer-based mathematical model designed to simulate keloid growth without further harming patients. This innovative agent-based model mimics interactions between skin cells and fibers, particularly collagen, which is overproduced in keloids. By using data from UC Irvine collaborators who studied skin samples from keloid edges, the model identifies three key cell types: CCL 19 (the leaders), Aspen (the followers), and immune cells (the besties).

The model begins with a simulated wound and tracks how these cells interact over time, aiming to predict the expansion of keloids. The researcher noted that the interactions leading to the most accurate predictions of keloid growth were identified, paving the way for potential treatments to combat these invasive scars.

This mathematical approach not only addresses keloid scars but also holds promise for broader applications in skin health, including treatments for cuts, burns, wrinkles, and even aging. The researcher concluded with an invitation for further exploration, emphasizing the exciting intersection of mathematics and healthcare.